McGill University Department of Chemistry Analytical/Environmental Chemical Biology Chemical Physics Materials Chemistry Synthesis/Catalysis  
   
Synthesis/Catalysis Profs.
Arndtsen, Bruce
Auclair, Karine
Bohle, Scott
Butler, Ian
Chan, Tak-Hang
Cosa, Gonzalo
Damha, Masad
Eisenberg, Adi
Farrell, Patrick
Friščić, Tomislav
Gleason, James
Gray, Derek
Guindon, Yvan
Harpp, David
Hay, Allan
Kakkar, Ashok
Lennox, Bruce
Li, C.J.
Lumb, Jean-Philip
Marchessault, Robert
Moitessier, Nicolas
Moores, Audrey
Perepichka, Dima
Shaver, Alan
Sleiman, Hanadi
Tsantrizos, Youla
van de Ven, Theo
Youla S. Tsantrizos
Youla S. Tsantrizos

Professor

Education
B.Sc. (McGill University, 1977)
M.Sc. (McGill University, 1979)
Ph.D. (McGill University, 1990)
Postdoctoral Fellow (Brown University, 1991)

Positions Held
Group Leader/Distinquished Scientist (Boehringer Ingelheim, 2003-2008)
Senior Research Scientist (Boehringer Ingelheim, 1998-2003)
Visiting Professor (Stanford University, 1997)
Assistant & Associate Professor (Concordia University, 1991-97)
Professor Vanier College (1979 - 1987)

Awards Received
Queen Elizabeth II Diamond Jubilee Medal 2012
Fessenden Professorships in Science Innovation, 2011
International Boehringer Ingelheim Research & Development Award, 2000
Dean's Honour List, McGill University 1990
Canadian Pacific Fellowship in Biotechnology, 1988-1990
Equipes et Seminnaires (Collegial) FCAR, 1986 - 1988

Office: 316
Phone: (514)398-3638
Email: Youla.Tsantrizos@mcgill.ca
Web Page: http://tsantrizos-group.mcgill.ca

Links:
Member of the protein structural research center GRASP http://grasp.mcgill.ca
Mentor in the McGill Canadian Institute of Health Research Training Program in Drug Development ( http://www.medicine.mcgill.ca/trainingindrugdev/)

Lab: Pulp & Paper 210
Lab Phone: 514-398-5675

Research Themes:
Chemical
Biology
Synthesis/
Catalysis

Research Description:
Our projects focus on the design and synthesis of small molecule ligands that can bind to mammalian or microbial targets modulating their function. Our main objective is to design chemical tools that can facilitate investigations into the biological role of proteins associated with a disease state.


Currently, a number of our projects involve structure-based ligand design targeting the human enzyme farnesyl pyrophosphate synthase (hFPPS). A key objective of these projects is to synthesize novel active site or allosteric site inhibitors of hFPPS that could potentially serve as “leads” for the design of better therapeutic agents for the treatment of osteoporosis, cancer and viral infections. However, the ultimate goal of these studies is to provide greater insight into the biological significance of post-translational prenylation of proteins and elucidate the role of hFPPS in the innate immune response during viral infections.


Currently Teaching:
CHEM-211F Organic Chemistry 1 Lectures
CHEM-212F Introductory Organic Chemistry 1
CHEM-224F Organic Chemistry Laboratory 1
CHEM-382 Organic Chemistry: Natural Products
   
801 Sherbrooke St. W. Montréal, Québec H3A 2K6 tel: 514-398-6999 fax: 514-398-3797   
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