| Youla S. Tsantrizos | |||||||||||
ProfessorEducationB.Sc. (McGill University, 1977) M.Sc. (McGill University, 1979) Ph.D. (McGill University, 1990) Postdoctoral Fellow (Brown University, 1991) Positions Held Group Leader/Distinquished Scientist (Boehringer Ingelheim, 2003-2008) Senior Research Scientist (Boehringer Ingelheim, 1998-2003) Visiting Professor (Stanford University, 1997) Assistant & Associate Professor (Concordia University, 1991-97) Professor Vanier College (1979 - 1987) Awards Received Queen Elizabeth II Diamond Jubilee Medal 2012 Fessenden Professorships in Science Innovation, 2011 International Boehringer Ingelheim Research & Development Award, 2000 Dean's Honour List, McGill University 1990 Canadian Pacific Fellowship in Biotechnology, 1988-1990 Equipes et Seminnaires (Collegial) FCAR, 1986 - 1988 Office: Pulp & Paper 108 Phone: (514)398-3638 Email: Youla.Tsantrizos@mcgill.ca Web Page: http://tsantrizos-group.mcgill.ca Links: Member of the protein structural research center GRASP http://grasp.mcgill.ca Mentor in the McGill Canadian Institute of Health Research Training Program in Drug Development ( http://www.medicine.mcgill.ca/trainingindrugdev/) Lab: Pulp & Paper 210 Lab Phone: 514-398-5675 Research Themes:
Research Description: Our projects focus on the design and synthesis of small molecule ligands that can bind to mammalian or microbial targets modulating their function. Our main objective is to design chemical tools that can facilitate investigations into the biological role of proteins associated with a disease state. Currently, a number of our projects involve structure-based ligand design targeting the human enzyme farnesyl pyrophosphate synthase (hFPPS). A key objective of these projects is to synthesize novel active site or allosteric site inhibitors of hFPPS that could potentially serve as “leads” for the design of better therapeutic agents for the treatment of osteoporosis, cancer and viral infections. However, the ultimate goal of these studies is to provide greater insight into the biological significance of post-translational prenylation of proteins and elucidate the role of hFPPS in the innate immune response during viral infections. Currently Teaching: CHEM-211F Organic Chemistry 1 Lectures CHEM-212F Introductory Organic Chemistry 1 CHEM-224F Organic Chemistry Laboratory 1 CHEM-382 Organic Chemistry: Natural Products |
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