| James L. Gleason | |||||||||||
Associate ProfessorB.Sc. (McGill University, 1989)Ph.D. (University of Virginia, 1994) NIH postdoctoral fellow (California Institute of Technology) Phillip Morris Graduate Fellowship (1989-1990) DuPont Graduate Fellowship (1990-1991) Pratt Graduate Fellowship (1990-1992) National Institutes of Health Postdoctoral Fellowship (1994-1996) Bio-Mega/Boehringer Ingelheim Young Investiagtor Award (1996) Research Innovation Award (Research Corporation) (1997) Office: 220 Phone: (514)398-5596 Email: Jim.Gleason@McGill.ca Web Page: http://www.gleason-group.mcgill.ca/ Lab: Otto Maass 237 and 238 Lab Phone: (514)398-6225 Research Themes:
Research Description: Research in our group focusses on many areas of organic chemistry. We are interested in the development of new reaction methodologies, particularly those which form new carbon-carbon bonds in a highly stereoselective fashion. In this area, we are developing new methods for quaternary carbon formation, asymmetric aldol and Reformatzky condensations and cycloisomerizations of enynes to form carbo- and oxacycles. We also have several total synthesis efforts underway. The focus here is to not only develop viable routes to interesting target molecules, but also to develop new synthetic methods along the way. Finally, we are developing methods in the emerging field of dynamic combinatorial chemistry. This research seeks to use a drug target (such as an enzyme or receptor) to influence a combinatorial synthesis such that the target identifies and amplifies the synthesis of its own best ligand. Currently Teaching: CHEM-222F Introductory Organic Chemistry 2 CHEM-244F Organic Chemistry Laboratory 2 CHEM-522 Stereochemistry CHEM-572 Synthetic Organic Chemistry CHEM-629 Organic Synthesis |
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